C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

Elixirgen Therapeutics, Inc. is a clinical-stage biotechnology company focused on the treatment of rare diseases and aging-associated diseases using its ZSCAN4 technology and mRNA platform ...

After testing the targeting capabilities of several different DNA binding domains, the team settled on a zinc finger protein—a little curlicue-shaped protein that performed the best in terms of ...

Sp1 is a protein that has multiple zinc-finger motifs, or regions known to bind to zinc; however, the inclusion of EDTA, an agent that chelates metal ions, inhibits zinc binding. Thus, notice that ...

Another result of this research are zinc finger nucleases. These artificial enzymes consist of a sub-unit that recognizes the desired DNA sequence, and a DNA-cutting part of a restriction enzyme.

The monocytic leukemia zinc-finger protein (MOZ) gene is rearranged in t(8; 16)(p11; p13) and inv(8)(p11q13) associated with acute myeloid leukemia. The other fusion partners involved are CBP and ...

By creating gene editors not found in nature, or optimizing existing editors, AI can improve the accuracy, effectiveness, and accessibility of gene editing.

Co. Ltd. has described histone acetyltransferase KAT6A (monocytic leukemia zinc finger protein; MOZ; MYST-3) and/or histone acetyltransferase KAT6B (MOZ2; MYST-4) inhibitors reported to be useful for ...

Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. has described histone acetyltransferase KAT6A (monocytic leukemia zinc finger protein; MOZ; MYST-3) and/or KAT6B (MOZ2; MYST-4) ...