Aconsortium of 17 laboratories worldwide has presented results contradicting a highly cited study that described a technique to create conditional knockout mice using CRISPR. The preprint, published ...

A minimum of 3 positive founders will be delivered. To produce CRISPR/cas9-mediated gene indels to generate knock-out mice or rats. The investigator will provide or purchase the CRISPR gRNA(s). TGEF ...

This is going to help those utilizing more clinically relevant lines because we have, in some instances, seen improvements in the knockout efficiencies when using a synthetic sgRNA format compared to ...