3D structure of the social amoeba genome sheds light on the transition to multicellularity
Each cell of the human body contains two meters of DNA. The whole secret lies in the intricate three-dimensional arrangement ...
How do cells respond to changes? New study finds it's not all in the genes
Cells are constantly on the move, whether in a developing embryo or metastatic cancer. But how do cells adapt to the new ...
eLife1d
Structure-guided secretome analysis of gall-forming microbes offers insights into effector diversity and evolution
This study presents an important discovery regarding the diversity and evolution of gall-forming microbial effectors. Supported by convincing computational structural predictions and analyses, the ...
Unraveling structure and function relationships in synthetic cell receptors
Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...
eLife3d
SATAY-based chemogenomic screening uncovers antifungal resistance mechanisms and key determinants of ATI-2307 and chitosan sensitivity
This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing ...