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C&EN2d
Active Site Binding and Catalytic Role of Bicarbonate in 1,4-Dihydroxy-2-naphthoyl Coenzyme A Synthases from Vitamin K Biosynthetic Pathways
1,4-Dihydroxy-2-naphthoyl coenzyme A (DHNA-CoA) synthase, or MenB, catalyzes a carbon–carbon bond formation reaction in the biosynthesis of both vitamin K1 and K2 ... Here we determine the crystal ...
C&EN2d
Stabilization of the Second Oxyanion Intermediate by 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase of the Menaquinone Pathway: Spectroscopic Evidence of the Involvement of a ...
1,4-Dihydroxy-2-naphthoyl-coenzyme A (DHNA-CoA) synthase ... changes induced by deprotonation of the free inhibitors in a basic solution. Dissection of the structure–affinity relationships of the ...