These toxins block exocytosis (the process of secretion, involving fusion of the transport vesicle with the plasma membrane) by proteolysis of one or another of the presynaptic SNARE molecules ...

Extracellular vesicles play a vital role in cell biology, modulating communication and signaling, with potential applications in diagnostics and therapeutics.

How is this endocytic activity and subsequent formation of fusion-competent vesicles coupled to exocytosis? In order to delineate the underlying mechanisms we developed a new neuronal culture system, ...

Here, the authors developed a trigger-inducible calcium importer to allow various trigger compounds of interest (e.g. FDA-approved drugs) to control exocytosis of insulin or other therapeutic ...

Moreover, the protein's effects on endocytosis, exocytosis, and vesicle circulation are closely related to synaptic transmission. In the central nervous system, the release of calcium-dependent ...

The study introduces new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. This ...

The year was 1975, before cell phones and email became ubiquitous, and Alex Capron remembers watching scientists lining up at a payphone during breaks at a conference. The payphone was in the main ...

Through interviews with the artist and those closest to him, co-directors Molly Bernstein and Philip Dolin chronicle Spiegelman’s career in a standard doc portrait. From his father, a Holocaust ...

For the first time, Midsomer Murders is heading for the stage! Based on Caroline Graham’s book and the hit ITV series, Midsomer Murders: The Killings at Badger’s Drift will embark on a tour later this ...

Pangdemonium’s A Doll’s House, Part 2 is a rehabilitation of maligned husband Torvald, persona non grata of Norwegian playwright Henrik Ibsen’s groundbreaking A Doll’s House that was first ...

David Johansen, the wiry, gravelly-voiced singer and last surviving member of 1970s glam and protopunk band the New York Dolls who later performed as his campy, pompadoured alter ego, Buster ...