A new study from Auburn University provides new insights into neuronal connections, offering hope for the treatment of ...

These toxins block exocytosis (the process of secretion, involving fusion of the transport vesicle with the plasma membrane) by proteolysis of one or another of the presynaptic SNARE molecules ...

The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance of dopaminergic neurons and the regulation of vesicle exocytosis of α-synuclein ...

Our team has conducted the first genome-wide CRISPR screens to systematically identify new regulators of regulated exocytosis—a type of vesicle fusion—in mammalian cells. These screens revealed a ...