Researchers from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences constructed a ...

How well our brain functions depends heavily on the performance of our nerve cells. That is why they are regularly checked for their proper function -- defective cell components are marked, disposed ...

Pfizer has pledged a whopping $1 billion upfront for rights to an Arvinas drug for breast cancer from its protein degrader ... involved in the main ubiquitin proteasome pathway involved in ...

If they fail, they are marked with the protein ubiquitin ... However, inhibitors actually work on USP30 was not yet known on the molecular level. “One problem with the human protein USP30 is that it ...

Here, we highlight the contributions of these published works and place them into the broader context of ubiquitin biology and its clinical implications ... the authors reveal that the ...

Treatment with an mTOR inhibitor in 6-month-old TRGL/Q175 mice normalized lysosome numbers, alleviated aggresome pathology, and reduced mHTT, p62, and ubiquitin levels ... and also commented on its ...

PROTACs are small molecules that use the ubiquitin-proteasome system to remove unwanted proteins. They are a promising class of cancer-fighting drugs, but there are challenges with getting them ...