Using the cellular ubiquitin-proteasome system (UPS) to alter viral protein stability is a promising strategy for developing live-attenuated vaccines. Researchers first engineered PROTAR influenza ...

For example, if you step on something sharp, the nerves in your foot send a message through neurons to your central nervous system that says, "Hey, this hurts." Your brain and spinal cord respond ...

For the WHO, the burden of brain disorders constitutes 35 to 38% of the total burden of all diseases (data based on DALYs: disability adjusted life years), compared to 12.7% for cancer and 11.8% ...

PROTACs are small molecules that use the ubiquitin-proteasome system to remove unwanted proteins ... them into clinically useful treatments for diseases,” said study author Hui-Kuan Lin ...

These findings could also be relevant for Alzheimer's disease and other neurodegenerative conditions. Spastic paraplegia type 15 is characterized by the progressive loss of neurons in the central ...

Long-term consumption of ultraprocessed foods (UPF) is associated with nonmotor prodromal Parkinson disease (PD) features.

Ubiquitination, an essential post-translational modification, controls various cellular functions by attaching ubiquitin to ...

To avoid recognition in this space, a strain of the bacterial tomato disease Pseudomonas syringae manipulates plants by producing a substance called glycosyrin. This substance suppresses the ...

Amyotrophic lateral sclerosis (ALS) is a relatively rare but very serious disease of the nervous system. A cure is not ... 43 from aggregation via SUMO–ubiquitin networks, Nature Chemical ...

Multiple sclerosis is a chronic condition affecting the central nervous system (CNS), where the immune ... to help manage symptoms and slow disease progression, including disease-modifying ...