Parabilis’s ERG degrader uses Helicon technology to bind directly to the ERG protein and, through its attached E3 ligand, directs the ERG protein to the ubiquitin-proteasome pathway for degradation.

The work has led to a new class of therapeutic targets associated with the ubiquitin-proteasome pathway that offers the potential for treatment of cachexia (also known as muscle atrophy) and other ...

Most unwanted cellular proteins are earmarked for proteasome-mediated degradation by multimers of the protein ubiquitin, which binds to ubiquitin receptors on the proteasome. Some proteins, however, ...

“Our findings provide direct evidence that the ubiquitin proteasome system is a crucial player in Alzheimer’s disease. This opens up a plethora of new targets for therapeutic intervention,” Glickman ...

And while cells typically tag proteins destined for proteasomal destruction with the small molecule ubiquitin ... “The midnolin-proteasome pathway catches proteins for ubiquitination-independent ...

"The mechanism we found is very simple and quite elegant," added ... by tagging them with a small molecule called ubiquitin. The tag tells the proteasome that the proteins are no longer needed ...

Here, cryo‐EM data show that it assembles into dimers and tetramers, and efficiently extends ubiquitin chains on primed substrates, such as AKIRIN2. UBR5 dimers and tetramers assemble through distinct ...

It exists in the cytoplasm and nucleus of cells, but the exact function of survivin in different subcellular locations retained unclear updates due to the lack of effective and simple technical ...

BCAA deprivation stimulates the degradation of acetylated BCAT2 through by the ubiquitin–proteasomeubiquitin-proteasome pathway (Lei et al ... SUMOylation is a relatively simple process. As described ...