The work has led to a new class of therapeutic targets associated with the ubiquitin-proteasome pathway that offers the potential for treatment of cachexia (also known as muscle atrophy) and other ...

A new strategy for delivering bulky PROTACs to cancerous cells successfully utilizes the CD36 protein pathway on cells’ surfaces.

Standardized nutrition care pathways aid in the detection of malnutrition and the identification of patients who may benefit from enteral nutrition. Patients with inadequate caloric intake may ...

Taken together, these findings demonstrate that interferon triggers PARP14-mediated ADP-ribosylation in p62 bodies, which requires an active ubiquitin-proteasome ... prompting us to explore the ...

These newly identified pathways could be leveraged to develop innovative therapeutic treatments. According to Dr. David Aranda, postdoctoral researcher at GRIB and lead author of the study ...

and the other to an enzyme involved in the main ubiquitin proteasome pathway involved in breaking down proteins. Arvinas has previously signed PROTAC-based research collaborations with Bayer ...

“The ubiquitin-proteasome system in the tumor immune microenvironment ... thereby activating the p53 pathway (10). The review also provides a thorough summary of the current research on the potential ...

A pinched nerve occurs when there is pressure or force on an area of a nerve, causing it to send pain signals to the brain. Most cases are mild, and a person can often treat them at home. In this ...

"What we were noticing is that ubiquitin binds to a lot of other proteins ... research shows how the genders use different molecular pathways to store traumatic memories. "There's an empathy ...