In recent years, the number of developmental pathways in plants that have been shown to involve ubiquitin has ... in processes other than simple targeting to the proteasome. It is now known ...

A major pathway for protein ... 76–amino acid ubiquitin monomers via a three-step process of ubiquitin activation and substrate recognition. Polyubiquitination targets proteins for recognition and ...

The ubiquitin–proteasome ... double duties in these two pathways indicates that there is a deeply rooted mechanistic connection between transcription and the Ub–proteasome system that we ...

And while cells typically tag proteins destined for proteasomal destruction with the small molecule ubiquitin ... “The midnolin-proteasome pathway catches proteins for ubiquitination-independent ...

This overall process of protein degradation is termed the ubiquitin– proteasome pathway (UPP). More than 80% of the proteins within the cells are degraded through this pathway, including the ...

Protein turnover is crucial in maintaining cellular homeostasis and this process is largely controlled by the Ubiquitin Proteasome Pathway (UPP). The pathway consists of an enzymatic cascade that ...

The work has led to a new class of therapeutic targets associated with the ubiquitin-proteasome pathway that offers the potential for treatment of cachexia (also known as muscle atrophy) and other ...

We present preliminary findings on the application of of a new surface library, SeraFILE™, to the functional characterization of the Ubiquitin/Proteasome pathway. Important results are: markedly ...

Proteasome inhibitors in multiple myeloma: 10 years later. Blood 2012;120:947–59. 4 Rolfe M, Chiu MI, Pagano M. The ubiquitin-mediated proteolytic pathway as a therapeutic area. J Mol Med (Berl).

Protein turnover is crucial in maintaining cellular homeostasis and this process is largely controlled by the Ubiquitin Proteasome Pathway (UPP). The pathway consists of an enzymatic cascade that ...