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C&EN21d
Ubiquitin Azapeptide Esters as Next-Generation Activity-Based Probes for Cysteine Enzymes in the Ubiquitin Signal Pathway
Department of Biochemistry and Biophysics, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas 77843, United States ...
Frontiers1mon
Protein modifications in hepatic ischemia-reperfusion injury: molecular mechanisms and targeted therapy
Overview of PTMs of proteins in HIRI, emphasizing their key roles, interactions, and regulation of signaling pathways ... via the ubiquitin-proteasome system (UPS) (34). Polyubiquitin chains, form ...
C&EN1mon
Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation
Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York ...
Frontiers1mon
Human papillomavirus E2 proteins suppress innate antiviral signaling pathways
This study elucidates the role of HPV11 and HPV16 E2 proteins in modulating innate immune responses, focusing on their interaction with key innate antiviral signaling pathways. We demonstrate that ...
ki.se1y
The ubiquitin/proteasome system in neurodegenerative diseases and cancer – Nico Dantuma's Group
Our major objectives are to understand the role of the ubiquitin/proteasome system in the development of neurodegenerative diseases and cancer and to explore the therapeutic potential of modifiers of ...