By addressing this technical gap, our study provides direct evidence of the crosstalk between CK2α O-GlcNAcylation and the ubiquitin-proteasome pathway and how its downstream phosphorylation is ...

Key takeaways: AMX0114 was developed to target calpain-2, a driver of axonal neurodegeneration. A pending clinical trial will evaluate safety and efficacy of the novel therapeutic. The FDA has ...

AMX0114 is an investigational antisense oligonucleotide targeting calpain-2, a calcium-activated protease believed to play a role in ALS disease progression.

Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system. In this phase 3, open-label, randomized ...

Importantly, these structures are unaffected by autophagy inhibition, but depend on ubiquitination and proteasome activity. Taken together, these findings demonstrate that interferon triggers ...

Calpain-5 subsequently degrades two transcription factors, which coordinate the activation and deactivation of various target genes. There might be more transcription factors to be found as the ...

As in skeletal muscle, the ubiquitin/proteasome system plays an important role in cardiac protein degradation. 8 Unlike skeletal muscle, however, there is no heart-specific calpain that might ...

Among the UPS components, ubiquitin-conjugating enzymes, such as ubiquitin-conjugating enzyme E2 J1 (UBE2J1), have emerged as key players in cancer dynamics, especially in prostate cancer (PCa ...

The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by ...

Our major objectives are to understand the role of the ubiquitin/proteasome system in the development of neurodegenerative diseases and cancer and to explore the therapeutic potential of modifiers of ...

The researchers found that USP11 chopped ubiquitin from 20 lysine residues, exposing them to acetylation. Tau acetylated at lysine 281 (K281Ac) was three times as insoluble as wild-type tau, they ...