Gut Microbiota in Immuno-Oncology: A Practical Guide for Medical Oncologists With a Focus on Antibiotics Stewardship Bispecific antibodies (bsAbs) have emerged as a novel class of therapeutics, ...

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K. Centre for Targeted Protein Degradation, School of Life Sciences, ...

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York ...

"Cells have two important 'junk compartments': the lysosome and the proteasome," Silverman said. "They collect junk and other components that are not useful to the cell, chew them up and get rid ...

Taken together, these findings demonstrate that interferon triggers PARP14-mediated ADP-ribosylation in p62 bodies, which requires an active ubiquitin-proteasome system. Interferon induces the ...

A model of the proteasome. Image credits: RCSB. For decades, the proteasome has been considered a simple molecular shredder. It chews up used or damaged proteins and feeds them to T cells to help ...

PCSK9 disrupts TSPO-GRP78 interactions, resulting in TSPO misfolding and subsequent degradation of TSPO by the ubiquitin-proteasome system. Reducing cardiac TSPO expression by gene therapy prevents ...

As the world’s population ages, neurodegenerative diseases are becoming more widely acknowledged as serious global health and socioeconomic issues. Although many resources have been devoted to the ...

In conclusion, our findings indicate that RNF5-mediated degradation of the HBV Core protein represents a novel antiviral mechanism that is independent of the canonical ubiquitin-proteasome pathway.