The ubiquitin-dependent proteasome phase separation may be linked to clearance of aggregates that causes neurodegenerative diseases. These results were published in Nature. Advanced Search ...

In transgenic mice expressing K6W mutant ubiquitin in the lens, the altered ubiquitin–proteasome system causes calpain hyperactivation, resulting in disease progression 136.

Success as An Anti-Cancer Agent Has Fueled Efforts to Discover Proteasome Inhibitors That Raise Proteins Levels with Beneficial Effects The ubiquitin proteasome system (UPS) provides a mechanism ...

The pathway consists of an enzymatic cascade that links the polypeptide cofactor Ubiquitin to specific protein targets, which mark them for degradation by the proteasome. This cascade is highly ...

Proteasome inhibitors are drugs that were initially designed to explore the activities of proteasomes. However, once the ubiquitin–proteasome pathway was discovered, the potential effects of ...

Proteasome collaborate with ubiquitin to degrade proteins. [Love Employee/Getty Images] Newly Identified Proteasomal Protein Disposal Mechanism Bypasses Ubiquitin Tagging. August 24, 2023.

The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins. As the maintenance of protein homeostasis is essential ...

A major pathway for protein degradation is initiated by the addition of multiple 76–amino acid ubiquitin monomers via a three-step process of ubiquitin activation and substrate recognition.

Celgene, Nurix Target Ubiquitin Proteasome by Michael McCoy September 21, 2015 | A version of this story appeared in Volume 93, Issue 37 ...