Rare loss-of-function variants in HECTD2 and AKAP11 confer risk of bipolar disorder
Scientists at deCODE genetics/Amgen have identified associations between bipolar disorder and rare loss-of-function variants ...
News Medical on MSN5d
Rare loss-of-function variants in HECTD2 and AKAP11 confer a risk of bipolar disorder
Bipolar disorder is characterized by extreme mood swings, bouts of mania or hypomania, and episodes of depression. It is a ...
Rolling Out10d
Surprising brain study reveals Parkinson’s treatment
Study reveals the structure of PINK1 protein, offering fresh hope for Parkinson's patients through potential targeted ...
deCODE genetics: Rare loss-of-function variants in HECTD2 and AKAP11 confer a risk of bipolar disorder
Scientists at deCODE genetics, a subsidiary of Amgen, reveal today in Nature Genetics associations between rare ...
Revolutionary Cancer Vaccine Targets All Solid Tumors
The method triggers immune responses that inhibit melanoma, triple-negative breast cancer, lung carcinoma, and ovarian cancer ...
GitHub11d
UBE2E3: Ubiquitin Conjugating Enzyme E2 E3 - A Study on Its Role in Human Genetics
The UBE2E3 gene encodes a ubiquitin-conjugating enzyme involved in the critical process of protein ubiquitination. Ubiquitination is a key post-translational modification that regulates protein ...
AlphaGalileo24d
An Upgraded Nuclease Prime Editor Platform Enables High-Efficiency Singled or Multiplexed Knock-In/Knockout of Genes in Mouse and Sheep Zygotes
CRISPR/Cas9 has revolutionized genome editing, but prime editing (PE) offers a more precise, DSB-independent approach. However, PE efficiency remains suboptimal, especially for large animal genetic ...
eLife6d
ImPaqT - A Golden Gate-based Toolkit for Zebrafish Transgenesis
Transgenic animals continue to play an essential role in many aspects of zebrafish research, including the development of disease models. The most widely used system for zebrafish transgenesis is the ...