Tyrosine kinase inhibitors, such as gefitinib (Iressa ™, ZD1839), block the EGFR. As a result, there is inhibition of cellular proliferation, promotion of apoptosis, and inhibition of anti ...

The JAK inhibitor CP-690550 was reported to show immunosuppressive effects by reducing the number of NK cells. [104] TK inhibitors with anti-inflammatory effects might also affect tumor immunity.

Olverembatinib, the company's novel next-generation tyrosine kinase inhibitor (TKI), received an upgraded recommendation in the CSCO Guidelines for the Diagnosis and Treatment of Leukemias in Children ...

Savolitinib is an oral, potent, and highly selective MET tyrosine kinase inhibitor ("TKI”) being jointly developed by AstraZeneca and HUTCHMED and commercialized by AstraZeneca. MET is a tyrosine ...

This study demonstrates that the tyrosine kinase inhibitors ALW-II-41-27 and ponatinib enhance the efficacy of MEK inhibition in multiple TNBC cell lines, suggesting potential for combination therapy.

Join us again at the only FREE TO ATTEND (for drug developers & academics) industry-dedicated summit focused on advancing the best-in-class kinase inhibitor products with enhanced specificity ...

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