A new drug targets RAS-PI3Kα pathways without harmful side effects. It was developed using high-performance computing and AI.

“If a drug had no effect on the tumor organoid, then this treatment would also have no effect on the patient – and vice versa,” said Oliver Sieber, the study’s corresponding author.

The research team used patient-derived PDAC cells with hiPSC-derived endothelial and mesenchymal cells to create fused pancreatic cancer organoid (FPCO).

The tumor organoid biobank proves useful for conducting drug sensitivity testing, drug screening, and toxicity assessments based on the heterogeneity of tumors.

In this crucial webinar, we explore the latest developments in cancer organoid (tumoroid) technology and its promising implications for drug screening. Discover how to establish next-gen tumoroid ...

A fundamental discovery by University of Missouri scientists could help solve one of the most frustrating challenges in ...

An automated bioprinting and imaging platform allows researchers to examine heterogeneous responses to anticancer drugs within a tumor organoid population. ... In a proof-of-concept Nature ...

Explore the latest developments in cancer organoid (tumoroid) technology and the promising implications for drug screening during this two-part webinar. In the first half, Colin Paul will discuss the ...

More information: Yanghua Shi et al, Patient-derived skin tumor organoids with immune cells respond to metformin, Cell Organoid (2024). DOI: 10.26599/CO.2024.9410001. Provided by Tsinghua ...

In experiments with IPTOs grown from brain metastases, the mini-tumors in the culture dish also accurately reflected the therapy results with targeted drugs—a decisive step towards personalized ...

Signet’s organoid models, derived from real-world cancer genomics data, can closely mimic human biology in 3D tissues to identify novel targets and evaluate drug efficacy with greater clinical ...

These and other 3D organoid models developed by Predictive Oncology substantially complement its AI-driven 2D platform and 3D spheroids, which utilize human tumor samples to accelerate drug ...