Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors. Hypoxic conditions help ...

The antibody PLT012 targets the fat transporter CD36 to restore immune responses in tumors, offering a new and promising ...

Researchers say, “It turns out SSRIs don’t just make our brains happier; they also make our T cells happier—even while ...

A single-cell analysis of nearly 18,000 white blood cells identifies a unique neutrophil subset characterized by type II ...

Additionally, treatment of Tregs or immunosuppressive macrophages with amezalpat ... tumor cells directly and by modulating immune suppressive cells and angiogenesis in the tumor microenvironment. In ...

said David Liberg, Chief Scientific Officer of Cantargia. Cancers escape the body's immune response by creating an immunosuppressive environment around the tumor. Beyond the local immunosuppression, ...

and immature heterogeneous MDSCs exhibit potent immunosuppressive properties. For example, MDSCs can overexpress ARG1 and NOS2. ARG1 could deplete arginine and impair T cell activation, and NOS2 ...

However, the immunosuppressive nature of the ... and their ability to alter the TME by inhibiting angiogenesis and reducing tumor fibrosis. Additionally, the authors explore strategies to optimize ...

In advanced cancers, vessel remodeling through unproductive angiogenesis generates a barrier to ... The mechanisms controlling the immunosuppressive phenotype of tumor endothelial cells are largely ...

In the tumor microenvironment, immunosuppressive cytokines and ... CAFS also possess reported angiogenesis capabilities, and play a key role in solid tumor progression and metastasis.