an older ADC that uses a tubulin inhibitor (antimitotic agent) DM1 as its payload. Third, Enhertu’s cysteine-based conjugation process is able to achieve a high drug-to-antibody ratio of around ...

5C). To normalize for sample-to-sample differences in fluorescence, the polyglutamylated tubulin antibody signal was normalized against the HiLyte488 signal from the microtubule seeds (see methods).

Product Namebeta Tubulin 2 antibodyAntibody TypePrimary AntibodiesProduct descriptionRabbit Polyclonal antibody to beta Tubulin 2 (tubulin, beta 2A)Tubulin is the major constituent of microtubules. It ...

Blots were stained first with a mixture of 1:10,000 rabbit anti-polyE antibody (clone IN105, Adipogen) and 1:10,000 mouse anti-α-tubulin antibody (clone DM1A, Sigma-Aldrich) for 1hr, washed, stained ...

Gennao Bio, a privately held genetic medicines company developing first-in-class, targeted nucleic acid therapeutics, today announced new preclinical results on the application of its non-viral, cell ...

The antibody-drug conjugate (ADC) field is witnessing an expansion in the variety of conjugation techniques, linker chemistry, and payloads being used, moving beyond traditional tubulin inhibitors to ...

Depleting γTuRC using any other mechanism, for example, anti-γ tubulin antibody coupled beads should also show similar effects. 5. The authors write in the discussion that γ-TuNA fails to activate ...

Coverslips were stained with a mouse monoclonal anti‐tubulin antibody (Sigma T9026, 1:2,000) for 1 h. After washing in PBS, coverslips were exposed to goat anti‐mouse Alexa Fluor 488 secondary ...

Primary antibodies for immunostaining were anti-RASSF1A antibody (Abcam, ab23950, 1:100), anti-acetylated-α-tubulin (acetyl-K40) antibody (Sigma, T7451, 1:500; Abcam, ab179484, 1:500), anti-BubR1 ...