WE have detected natural inhibitors of enzymes m microgram quantities. In our method, after gel electrophoresis of a sample presumed to contain inhibitory activity, the slab of gel was incubated ...

A novel topical formulation of a BRAF inhibitor significantly reduced acneiform rash associated with anti–epidermal growth factor receptor (EGFR) therapies in patients with colorectal cancer ...

In a recently published phase 2b extension study, adding narrow-band ultraviolet B (nbUVB) phototherapy to ritlecitinib, an oral Janus kinase (JAK) 3/tyrosine-protein kinase inhibitor, resulted in ...

The San Diego-based biotech has plans to take its myostatin inhibitor lead candidate, IBIO-600, to a Phase I study in early 2026, adds the CEO. The development of therapies to prevent muscle loss is ...

Genetic knockdown of DHX9 results in strong reduction of proliferation and survival in CRC cells characterized as MSI-H/dMMR, but not in microsatellite stable (MSS) CRC cells with proficient MMR (pMMR ...

Kinases are considered effective targets for drug development, especially with the notable success of kinase inhibitors in cancer treatment. Nonetheless, their capabilities in treating ...

1Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois. *Corresponding Author: Hilary A. Kenny, Department of Obstetrics and Gynecology, ...

"The initiation of this clinical trial marks an important milestone in advancing our novel WRN inhibitor program," said Anita Scheuber, M.D., Ph.D., Senior Vice President, Therapeutic Head, Oncology ...

Studies evaluating the potential synergy between QTX3544 and EGFR inhibitors (afatinib and cetuximab) in KRAS G12V-driven cancer cell lines and tumor models demonstrated: The mitogen-activated protein ...

Interest in developing selective inhibitors has produced tool compounds for the inactivation or degradation of AKR1C3 with varying degrees of selectivity among the 14 known AKR proteins. Selectivity ...

Led by AbbVie’s Humira, biologic TNF inhibitors transformed the treatment of autoimmune diseases over the past 20 years. However, the biologic modality can cause adverse effects and loss of ...