The researchers studied the pathogen that causes the African sleeping sickness known as Trypanosoma brucei. Trypanosomes have unique cell organelles, so-called glycosomes, which are essential for ...

Knockdown of the orthologous Trypanosoma brucei protein levels showed ZFP2 to be a positive regulator of specific target mRNA abundance. Trypanosoma cruzi; CCCH zinc finger protein; RNA-binding ...

Though many people have never heard of the disease, an estimated 300,000 Americans may unknowingly carry its causative agent, Trypanosoma cruzi. For years, Chagas was considered a problem only in ...

This rendering illustrates the critical interaction between gp82 on the Trypanosoma cruzi parasite and LAMP2 on the human cell membrane. The proximity of the two membranes, shown here, is a ...

The present study describes the antiprotozoal activities of four cyclopalladated compounds, [Pd(dmba)(μ-Cl)] 2, [Pd(dmba)(NCO)(isn)], [Pd(dmba)(N 3)(isn)] and [Pd ...

They usually bite during the daytime and their bites are usually quite painful. A human becomes infected with Trypanosoma brucei parasites when an infected tsetse fly feeds on his or her blood. The ...

Reference: Beaver AK, Keneskhanova Z, Cosentino RO, et al. Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei. Nature. 2024. doi: 10.1038/s41586-024-08151-z ...

Using a mouse model, the researchers showed that Trypanosoma brucei essentially plays a game of hide-and-seek by setting up shop in its hosts' tissues, allowing it to constantly change its ...

A parasite called Trypanosoma cruzi (T. cruzi) causes it. The disease infects up to 8 million people, mostly in Latin America. The CDC estimates that about 300,000 people in the U.S. have the ...

brucei, T. cruzi and Leishmania. The underlying determinants of nucleoside ... This landmark study sheds light on a long-standing puzzle of Protein kinase A activation in Trypanosoma. Extensive ...

The disease is spread through tsetse flies that feed on infected hosts. In 2015, 84 percent of Trypanosoma brucei infections (the main cause of the disease) were recorded in the Democratic ...