Thymic crosstalk between T cells and the thymus during T-cell priming shapes how the thymus grows and shapes itself.

Having established success in cancer, biopharma is now looking to leverage CAR T therapies against a new target, autoimmune disorders, with several early- to mid-stage readouts expected this year.

Thymic development insights The thymus gland plays a pivotal role in the immune system, as it is responsible for the maturation and selection of T cells, which are crucial for immune defense.

The thymus sits in front of the heart and is where T cells mature; its age-related decline is associated with cancer, infections and autoimmune conditions, according to a Dec. 4 release about the ...

The thymus is essential for both T-cell development and TCR repertoire selection, but undergoes changes in output and function across the life of a mouse (Kondo et al., 2019, Montecino-Rodriguez and ...

A thymus atlas reveals that immune foundations are set as early as 12 weeks post-conception. Researchers uncovered key T cell development processes, offering insights for engineering immune cells to ...

Find out what you need to know about your thymus gland and its function. Learn the signs of a problem and how to protect this gland.

The thymus, a vital organ for T cell maturation, undergoes structural and functional changes over time, further diminishing immune function.

Aging significantly impacts the immune system, notably through the involution of the thymus, which reduces T cell production. This decline weakens immune responses, making older adults more ...

T cells, integral to immune defense, undergo complex development and aging processes. This comprehensive study explores the mechanisms of T cell remodeling across the lifespan, focusing on thymus ...

How T-cell receptor (TCR) characteristics determine subset commitment during T-cell development is still unclear. Here, we addressed this question for innate-like T cells, mucosal-associated invari ...