With age, the thymus – located behind the breastbone – shrinks and the T-cell-producing areas are replaced with fatty tissues, while 'scarring' prevents regeneration. Treatments for cancer ...

In thymic epithelial cells, the research team upregulated a transcription factor called Forkhead box N1 (FOXN1), which had previously been implicated in age-related thymus shrinkage ... study suggests ...

He uses mouse models to study the thymus, the organ in which specialized immune cells ... The Dudakov Lab is working to understand the mechanisms underlying natural thymic regeneration so that new ...