According to Lo, the thymic M cells could be seen as being trained to function later, when needed, in the periphery in such a way that they are ready to communicate and interact with other cells.

“To this end, T cells undergo a very strict educational program in the thymus, during which both non-functional and self-reactive T cell clones are eliminated by means of positive and negative ...

Discovery of new cell type in thymus Biomedical scientists say the cells are like M cells in the gut and airways Date: September 6, 2023 Source: University of California - Riverside Summary ...

UC Riverside biomedical scientists have confirmed that newly discovered cells in the thymus are just like M cells, which are mostly known for their presence in the intestinal epithelium.

They play a key role during the development of the body’s immune system. The researchers at the Weizmann Institute of Science in Israel, led by Jakub Abramson, initiated the mouse study on the thymic ...

Abstract Thymic mimetic cells function beyond self-tolerance Development of immunocompetent T cells in the thymus is required for effective defence against all types of pathogens, including viruses, ...

Researchers at the Francis Crick Institute have identified stem cells in the human thymus for the first time. These cells represent a potential new target to understand immune diseases and cancer and ...

In contrast, the T cells generated by Russ lab’s organoids develop in a way that’s truer to the function of a real human thymus. In the results of a paper published March 23 in Stem Cell ...

Researchers have used pluripotent stem cells to make thymus organoids that support the development of patient-specific T-cells. The proof-of-concept work provides the basis for studying human ...

In Frontiers in Immunology, they described how they proved that CD41 + cell subsets in mouse lymph nodes predominantly expressed stromal cell and mast cell surface marker molecules.