Scientists have uncovered a crucial pathway that may help preserve thymic function as we age. The findings focus on ...

The University of Texas Health Science Center at San Antonio (UT Health San Antonio) scientists have uncovered a crucial pathway that may help preserve thymic function as we age.

In mouse model experiments, increasing FGF21 preserved both the size and function of the thymus, allowing for greater T-cell variation. Inside the labyrinth: How thymic structures rebuild Stromal ...

Using a fate-mapping autoimmune arthritis mouse model ... needed for T reg cells to enable immune responses to pathogens without triggering autoimmunity. Data now show that thymus-derived self ...

One of the mysteries of MDS is how the stem cells that give rise to these syndromes differ from that of the AML stem cell. Although there are several genetically-defined mouse models of MDS ...

However, discordance in mouse-to-human translation is a well-known ... such as influencing intestinal epithelial cells as Tuft cells by regulating the release of alarmins like thymic stromal ...

INmune Bio Inc., a clinical-stage biotechnology company targeting inflammation and immunology through the innate immune system, announced a major intellectual property milestone with respect to its ...

At its third attempt, Mesoblast has secured FDA approval for Ryoncil as a treatment for children with graft-versus-host disease, the first-ever approval for a mesenchymal stromal cell (MSC ...

Here, they are captured by the APCs, which then cause apoptosis among the antigen-specific T cells or differentiation in the suppressor T cells, which produce suppressive TGF-b. A breach in the ...

Using co-cultures, 3-Dimensional matrix imaging systems, mouse models and patient tissue samples, we study interactions between cancer cells and the extracellular matrix and stromal and/or immune ...