News

Study reveals intricate molecular detail of human DNA repair process
A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...
C&EN17h
Scientists design proteins that can change their shapes
In a new move, researchers have shown that protein design software can incorporate motion into its outputs. The resulting ...
Chromatography Online1d
Sil-DBO-PS: A Zwitterionic Phase for Enhanced HILIC of Polar Compounds
A joint study conducted by the Henan University of Technology (Zhengzhou, China) and the Food Laboratory of Zhongyuan (Henan ...
C&EN4d
Metadynamics Simulation of Prion Protein: β-Structure Stability and the Early Stages of Misfolding
Contribution from the Dipartimento di Chimica, Università di Firenze, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Italy, European Laboratory for Nonlinear Spectroscopy (LENS), Via Nello Carrara ...
Microscopic movies capture brain proteins in action, revealing new insight into shapes and functions
Our cells rely on microscopic highways and specialized protein vehicles to move everything—from positioning organelles to carting protein instructions to disposing of cellular garbage. These highways ...
Nature4d
Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization
Protein 4.1R in red blood cells has multiple binding sites for membrane and skeletal proteins and plays a critical role in maintaining cell morphology and membrane mechanical properties 1. The ...
eLife6d
Forecasting protein evolution by integrating birth-death population models with structurally constrained substitution models
This manuscript introduces a useful protein-stability-based fitness model for simulating protein evolution and unifying non-neutral models of molecular evolution with phylogenetic models. The model is ...