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AI tool reveals single-cell structure of chromosomes—in 3D
In a leap forward for genetic and biomedical research, two scientists at the University of Missouri have developed a powerful ...
eLife7d
Forecasting protein evolution by integrating birth-death population models with structurally constrained substitution models
This manuscript introduces a useful protein-stability-based fitness model for simulating protein evolution and unifying non-neutral models of molecular evolution with phylogenetic models. The model is ...
GEN2mon
Structure of Key Parkinson’s Disease Protein, PINK1, Seen for First Time
solving a decades-long mystery by determining the first structure of the human protein PINK1 bound to mitochondria. First discovered more than 20 years ago, PINK1 is a protein directly ...
Phys.org3mon
High-speed microscopy reveals real-time protein translocation across a bacterial membrane
Real-time dynamics of protein translocation across bacterial membrane using high-speed atomic force microscopy (HS-AFM). This visualization reveals how the SecYEG-SecA complex facilitates protein ...
scienceopen.com5mon
AF2-mutation: adversarial sequence mutations against AlphaFold2 in protein tertiary structure prediction
Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles. Cell Host & Microbe. 2020. Vol. 28:880–891 Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, et al.. Highly ...
IEEE6mon
Neural Network: A Machine Learning Technique for Tertiary Structure Prediction of Proteins from Peptide Sequences
Twenty physiochemical properties representation scheme for each amino acid and binary output discretization of real valued torsion angle ... prediction of residues for tertiary structure prediction ...
Frontiers7mon
DCMA: faster protein backbone dihedral angle prediction using a dilated convolutional attention-based neural network
An integral part of predicting tertiary structures is to predict interval structural properties, such as secondary structures, solvent-accessible surface area, backbone dihedral angles, and contact ...
Ars Technica7mon
Protein structure and design software gets the Chemistry Nobel
That structure is essential for the protein's function. Typically, figuring out the structure involves laborious biochemistry to purify the protein, followed by a number of imaging techniques to ...
Smithsonian Magazine7mon
Scientists’ Work on Protein Structure, Which Governs All Aspects of Life, Wins Nobel Prize in Chemistry
David Baker, Demis Hassabis and John M. Jumper shared the Nobel Prize in Chemistry on Wednesday for their work on protein structure. Atila Altuntas / Anadolu via Getty Images On Wednesday morning ...
Wired1y
Google DeepMind’s Groundbreaking AI for Protein Structure Can Now Model DNA
AlphaFold, software developed by Google’s DeepMind AI unit to predict the 3D structure ... of verified protein structures, much as an image generator learns from real photographs how to render ...
PNAS1y
Ultrafast end-to-end protein structure prediction enables high-throughput exploration of uncharacterized proteins
We present a deep learning-based predictor of protein tertiary structure that uses only a multiple sequence ... model as the input sequences in the MSA are changed, essentially in real time. Assuming ...