This valuable descriptive manuscript builds on prior research showing that the elimination of Origin Recognition Complex (ORC) subunits does not halt DNA replication. The authors obtain solid data ...

The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P. R. China The Biobank Center, The First Affiliated Hospital of ...

Despite the important role of human DNA polymerase α (Polα) in genome mutagenesis, there are no structural studies of Polα infidelity. The functional studies are sparse, lack high-resolution ...

Additionally, the scientists unexpectedly captured for the first time a detailed picture of how the "engine" driving the cellular replication machinery moves along DNA in human cells. Their ...

Abstract: We consider a nonlinear inverse problem where the unknown is assumed to be piecewise affine, which is motivated by an application in DNA replication analysis. Since traditional algorithmic ...

Many findings have evidenced that DNA tandem repeats and centrosomes are involved in morphogenesis, suggesting they have played a role in the evolution of shapes. This paper introduces computational ...

The cloning vector is usually a small part of a DNA strand that holds the genetic information that is needed for the replication of cells. Polymerase chain reaction (PCR) is another method that ...

and fidelity of replication in natural enzymes. To expedite the discovery of XNA polymerase activities, we created 22 separate repertoires of Tgo, a polB family DNA polymerase from the ...

It is said to be found during the start of a gene. DNA replication occurs in the S phase of the cell cycle. DNA replication is the process where DNA copies itself. This happens so that old ...