In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be helpful for learners to ...

This study reveals the step-wise establishment of nuclear speckle-associated domains (SPADs) during mouse embryogenesis.

Histone tails and their epigenetic modifications play crucial roles in gene expression regulation by altering the architecture of chromatin. However, the structural mechanisms by which histone tails ...

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus ...

During development, growth deforms tissues and organs. This is notably the case during the formation of new flowers in plants, as the tissue folds during young floral bud emergence. Here, we provide ...

According to the chromatin organization observed from our 4C-Seq data, IGFBP2, IGFBP5, and TNS1 were all part of the same TAD, which argues for high probability of contact between these genes ...

Recent epigenetics research has demonstrated that chromatin conformation plays an important role in various aspects of gene regulation. Chromosome Conformation Capture (3C) technology makes it ...