While it can be helpful for learners to begin with the linear presentation of how stretches of DNA form genes, this ...

This study reveals the step-wise establishment of nuclear speckle-associated domains (SPADs) during mouse embryogenesis.

CTCF, found at the boundaries of TAD domains, has been of special interest, recently, as it was shown to insulate TAD domains from each other rather than the genetic elements within a single TAD ...

How the genome sets its functional micro-architecture Date: August 17, 2017 Source: Ecole Polytechnique Federale de Lausanne (EPFL) Summary: Scientists now show how DNA is organized into specific ...

Nuclear architecture emerges at the awakening of the genome Max Planck scientists unravel when the 3-D organization of the genome in the nucleus arises during development ...

SARS-CoV-2 infection markedly restructured 3D host chromatin, featuring widespread compartment A weakening and A–B mixing and global reduction in intra-TAD chromatin contacts.

Collectively, the findings indicate that SARS-CoV-2 induces compartmentalization defects by reprogramming chromatin modification. Intra-TAD interactions.