Kidney fibrosis, a common endpoint of chronic kidney disease (CKD), is strongly linked to aging, with cellular senescence ...

This study aimed to elucidate the regulation of NAFLD-related liver fibrosis induced by HO-1 through the SIRT1/TGF-ß/Smad3 pathway. HO-1 induction and inhibition were established in C57BL/6J mice ...

Programs address the need for disease-modifying therapies targeting root causes of fibrosis Funding will support ... other CCN family members, including CTGF/CCN2 and WISP1/CCN4, on multiple ...

These include inhibitory (%) effects on inflammatory-related genes and fibrosis-related genes namely: Act2: up to 57%, TGFβ : up to 49.3 % (p<0.05), Ctgf: up to 44.2%, Ccl2: up to 77.28% (p<0.005 ...

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Dysfunctional TGF-Beta is a major contributor to lung diseases and contributes to inflammation in pulmonary fibrosis that leads ... for targets in the Wnt pathway, a key signaling pathway that ...

This study concludes that activation of the PPARβ/δ-AMPK pathway is an ... mainly responsible for fibrosis in the liver, in response to transforming growth factor β (TGF-β), the main stimulus ...

In the liver, TGF-β signaling is involved in maintaining liver homeostasis and responding to injury by modulating inflammation and fibrosis. HIPPO Pathway: The HIPPO pathway is a kinase cascade ...

Elexacaftor/tezacaftor/ivacaftor is an approved treatment for children and adults with cystic fibrosis. Development of docking stations on the respiratory tract is ...

Indeed, gene expression in healthy cells, compared with cystic fibrosis cells, shows an imbalance between two cell signaling pathways: the TGF-β pathway is hyperactivated, while the Wnt pathway ...

"Letrozole ameliorated MCD- and CCl4-induced liver fibrosis by suppressing the Yap-Ctgf pathway by partially modifying the expressions of Hsd17b13 and Cyp26a1, which reduced retinoic acid level in ...

“Letrozole ameliorated MCD- and CCl4-induced liver fibrosis by suppressing the Yap-Ctgf pathway by partially modifying the expressions of Hsd17b13 and Cyp26a1, which reduced retinoic acid level ...