including medullary thymic epithelial cells and various dendritic cell subsets, express and present a diverse array of antigens and may select distinct repertoires of natural T Reg cells.

The adult thymus provides a variety of specialized microenvironments that support and direct T cell differentiation and selection. In this review, we summarize recent advances in the understanding ...

The thymus is a small, inconspicuous organ, but it is also vital for a functional immune system. This is because it is the development site of the T-lymphocytes (T-cells), which play a central ...

They were able to reconstruct cell signals and movements. The researchers observed other cells in the thymus helping the T-cells to mature; the T-cells were given the chance to encounter many normal ...

The thymus is one of the organs of the immune system where T lymphocytes develop, a type of cells that is essential to fight infections and prevent cancer. Without them, it's impossible to live.

Its primary function involves T cell maturation. These cells help the body fight diseases, cancers, allergens, and more. The thymus also contains B cells. They help the thymus select the best T ...

to see if the organoids had the self-regulation capabilities of a real thymus, the scientists looked for markers of negative selection and T regulatory cell, or T reg, production. T regs are a ...

The thymus is also vital for the central self-tolerance mechanism, which focuses on clonal deletion of the self-reactive T-cells. The cTECs are responsible for a process of positive selection.

More information: J. Luke Postoak et al, Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection, Journal of Experimental Medicine (2022). DOI: 10.1084/jem.

A new study describes how the human thymus causes the list of friendly proteins that T cells should not attack. The research team identified, for the first time, the RNA molecules used to generate ...

The thymus is a small, inconspicuous organ, but it is also vital for a functional immune system. This is because it is the development site of the T-lymphocytes (T-cells), which play a central ...