The Cocoon® (from Lonza) is a functionally closed, sterile, efficient manufacturing platform, which combined with our ...

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors - a smart fighter that destroys cancer cells for days without tiring. USC biomedical engineers have ...

Navigating these challenges, he adds, makes patient selection all the more important for guiding treatment approaches. What are the biggest operational challenges in bringing CAR T-cell therapies ...

The mature cells serve as front-line soldiers in the body's defense system, fighting infection and disease. Without a thymus, Syanne doesn't have a working immune system. She can’t be exposed to ...

The thymus sits in front of the heart and is where T cells mature; its age-related decline is associated with cancer, infections and autoimmune conditions, according to a Dec. 4 release about the ...

Paulina Velasquez, MD, discusses the differences between T-cell receptor-based and chimeric antigen receptor T-cell therapies. Paulina Velasquez, MD, assistant faculty member, St. Jude Children’s ...

The thymus’ second role is to keep us safe from ourselves, by preventing autoimmunity. Both roles relate to the T-cell receptor, or TCR, which T cells use to recognize their targets. Each new T cell’s ...

Adoptive therapies based on CAR/TCR T cells—that is, T cells with an engineered chimeric antigen receptor (CAR) or a T-cell receptor (TCR)—have shown promise for a range of cancers, offering ...

Its primary function involves T cell maturation. These cells help the body fight diseases, cancers, allergens, and more. The thymus also contains B cells. They help the thymus select the best T ...

“The thymus is complicated because it creates a whole functional immune system and repertoire, and we know many component parts play a role in its performance,” he said. “We didn’t expect M cells to ...

The thymus resides in the chest between the lungs, right in front of and above the heart. In infants, the gland almost completely covers the heart. It pumps out immune cells called T cells ...

Huff Harvard Stem Cell Institute Research Support Fund and others.) Previous studies have shown that, although the thymus continues to produce T cells into adulthood, thymic activity decreases ...