Synthetic lethality is a concept in cancer research that refers to a situation where the simultaneous inactivation of two genes leads to cell death, while the inactivation of either gene alone ...

IMPACT Therapeutics (IMPACT), a biopharmaceutical company focusing on the discovery and development of targeted anti-cancer therapeutics based on synthetic lethality, announced that Senaparib capsules ...

Researchers from Tango Therapeutics Inc. have unveiled DNA ligase 1 (LIG1) as a potential new therapeutic target for synthetic lethality in BRCA1-mutant cancers after CRISPR/Cas9 screening.

RNAi as a tool for functional genomics & identification of synthetic lethal interactions RNAi is the mechanism whereby introduction of dsRNA into a cell results in the degradation of a mRNA ...

Ideaya Biosciences ( ($IDYA) ) has released its Q4 earnings. Here is a breakdown of the information Ideaya Biosciences presented to its investors.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License . Synthetic lethality approaches in BRCA1/2-mutated cancers have focused on ...

Beyond demonstrating the efficacy of YJ1206, our work underscores the potential of precision medicine approaches that exploit synthetic lethality and pathway vulnerabilities. The promising preclinical ...

Canada has named a former deputy commissioner with the Royal Canadian Mounted Police as the country’s fentanyl czar ...

Design RNA sequencing was performed to screen potential targets for PARPi sensitivity. The synthetic lethal effects were verified in patient-derived xenograft (PDX), xenograft and patient-derived ...

There's only one realistic way to at least slow down the crisis. Persuade Americans to not take illicit drugs and help those ...