According to the company, the therapy comprises a phosphorodiamidate morpholino oligomer, which is conjugated to a fragment antibody that attaches to the transferrin receptor 1, facilitating the ...

DYNE-251 consists of a phosphorodiamidate morpholino oligomer (PMO) conjugated to a fragment antibody (Fab) that binds to the transferrin receptor 1 (TfR1), which is highly expressed on muscle.

DYNE-251 consists of a phosphorodiamidate morpholino oligomer (PMO) conjugated to a fragment antibody (Fab) that binds to the transferrin receptor 1 (TfR1), which is highly expressed on muscle. It is ...

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic Department of Physical and Macromolecular Chemistry, Faculty of ...

This study revealed that, by binding to lipoproteins, cholesterol-conjugated heteroduplex oligonucleotides (Chol-HDOs) can remain in the bloodstream for longer and reach brain tissue much more ...

Consequently, the catalytic atroposelective synthesis of enantiopure atropisomers has garnered considerable attention. A variety of synthetic strategies involving metal catalysis or organocatalysis ...

This study provides fundamental insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the ...

Just as detailed blueprints and clay bricks are essential to construction workers, shorter synthetic versions of these two molecular workhorses-peptides and oligonucleotides-are crucial to ...