Here we report the structure of an entire HIV-1 genome at single nucleotide resolution using SHAPE, a high-throughput RNA analysis technology. The genome encodes protein structure at two levels.

The role of the structure and organization of the host genome in HIV-1 infection is not well understood. Using a cell culture model based on brain immune microglia cells, an international research ...

“The capsid shell acts as an ‘invisibility cloak’ that hides the virus’ genetic information, the genome ... to understand its structure to solve it.” Sarafianos and his team created the most complete ...

"Characterizing the structure of HIV RT was a critical turning point in ... Repetitive elements in the genome such as HERV-K are frequently overexpressed in cancer and elicit biological viral ...

Source: University of Minnesota Citation: Researchers determine structure of protein that mutates DNA of the AIDS virus HIV-1 (2008, February 20) retrieved 22 December 2024 from https://phys.org ...

Shape of things to come: Structure of HIV coat could lead to new drugs. ScienceDaily . Retrieved May 22, 2025 from www.sciencedaily.com / releases / 2009 / 11 / 091112121559.htm ...

“The HIV field has missed this modification in physiological RNA structure and HIV genome for more than 30 years,” Dr. Rana noted. “I will not be surprised if other viruses with RNA genomes ...

In the long battle to create an effective HIV vaccine, scientists have made a major leap forward. A new study shows that a ...

The enzyme RT of HIV-1 is responsible for copying the viral single-stranded RNA genome to double-stranded DNA (dsDNA) in the cytoplasm of infected cells. This 117-kDa heterodimeric (p66 and p51 ...

A new technique using electron tomography and subtomogram averaging at Diamond's electron Bio-Imaging Centre (eBIC), has solved the structure ... (HIV) is a retrovirus which has its RNA genome ...

A typical person's genome contains more than half a ... His lab's discoveries about HIV reverse transcriptase structure and function guided the discovery of novel medications for HIV infection.