BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce ...

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce ...

Diabetes is a metabolic disorder caused by dysfunction in the pancreas, the organ responsible for regulating blood sugar levels. Within the pancreas, islet cells secrete insulin to lower blood sugar.

The local stem cell environment (niche) is vital for stem cell maintenance and function in many tissues, and tenascin C in particular has been shown to play an important role within stem cell niches ...

Driven by growth factors and cytokines derived from the stem cell niche and surrounding immune cells, multiple signaling pathways tightly regulate ISC self-renewal and differentiation. Despite ...

Schematic Overview of the Development of a Bespoke Islet-specific Microenvironment Using Bioprinting Technology to Enhance ...