Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators of liver fibrosis—have a commanding role in ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to ...

Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators in liver fibrosis—have a commanding role in ...

Anyone who has tried to lose weight by cutting calories knows the frustration—after initial success, weight loss slows down or stops completely. This happens because the body adapts to lower calorie ...

A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...

This suggests that stellate cells play a previously unknown role in controlling liver metabolism by directing other cell types, introducing a new mode of cell-to-cell communication. Although fat ...

Hepatic stellate cells reside between the hepatocytes and small blood vessels in the liver. They are characterised by the presence of lipid droplets and thin protrusions extending around the blood ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

New research suggests restoring stellate cells to their healthy and protective state could simultaneously reduce liver scarring and improve liver function. Researchers from Columbia University and ...