To our knowledge, this is the first report to demonstrate that IL-4 can protect against spontaneous diabetes in NOD mice in an Ad-based systemic gene therapy approach. Our experimental approach ...

A research team has now developed a humanized mouse model that spontaneously develops Type I diabetes and the full range of complications experienced by diabetes patients. That allows study of the ...

Next, the scientists turned their attention to non-obese diabetic (NOD) mice. These animals spontaneously develop diabetes because their overly aggressive immune systems readily provoke beta (insulin) ...

The study, done in mice ... can spontaneously convert to beta cells without any interference from the researchers,” says Andrew Rakeman, the scientific program manager for the Juvenile Diabetes ...

Autoantibodies against GFAP may represent a new and early serum marker of high diabetes risk in NOD mice. B-and T-cell autoimmunity to pSC constituents in NOD females. a, NOD mice, but not C57BL/6 ...

While the study adds to the overall knowledge about diabetes, it is the mouse model that holds the real potential. In the new model, mice spontaneously develop Type I diabetes and, importantly ...

In the study, researchers worked with mice bred to spontaneously develop diabetes, the classic animal model for studying the disease. However, this particular group was also bred to carry a ...

The incidence of spontaneous diabetes dropped from 85 percent in controls to 65 percent in treated mice. In mice with prediabetes, treatment with hyperbaric oxygen was associated with reduced ...

Wenzhou Medical University researchers have reimagined the spleen as a viable site for islet transplantation, enabling ...

While the study adds to the overall knowledge about diabetes, it is the mouse model that holds the real potential. In the new model, mice spontaneously develop type 1 diabetes and, importantly ...