In vitro generation of DCs from mouse and human tissues such as bone marrow and peripheral blood monocytes, has been widely used to study their immunological functions. In chicken, DCs have mainly ...

Sorted classical and non-classical monocytes were cultured in the presence of 100 ng/mL M-CSF for 3 days or an additional 24 hours with RANKL (DC-STAMP ... therapies interfere with monocyte-derived ...

A recent study using a large cohort of organ transplantation donors as source of lymphoid organs, including the spleen, has shown the most complete characterization of human spleen immune cells ...

In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...

We identify the fat body-derived cytokine, Upd2, in targeting and inducing JAK/STAT signaling in tracheal progenitors to maintain their directional migration. Perturbation of either Upd2 production in ...

The authors provide convincing evidence that the fat body, located near the trachea, secretes vesicles containing the Upd2 cytokine and that affecting JAK-STAT signaling results in aberrant migration ...

49 Extramedullary hematopoiesis has been observed in tissues such as the liver, spleen, and adipose tissue. In these cases, pathogenic stimuli lead to the recruitment of HSC/HSPCs from the bone marrow ...

In this article, we propose a novel pathogenic mechanism whereby CD14+monocyte-derived oxidised mtDNA induces IFN stimulatory gene (ISG) expression in the rare childhood autoimmune disease JDM. We ...

Commensal bacteria, TNF and interferon-γ inhibited human DC miR-10a expression in vitro. Anti-TNF mAb treatment significantly promoted miR-10a expression, whereas it markedly inhibited NOD2 and ...