This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

Department of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, China ...

Tagworks initiated first-in-human phase 1 clinical development of TGW101 in a multicenter, open-label, dose-escalation trial in patients with advanced solid tumours. The primary objectives of the ...

We found that arginine limitation in pancreatic tumors perturbs saturated and monounsaturated fatty acid synthesis by suppressing the lipogenic transcription factor SREBP1. Synthesis of these fatty ...

Interleukin-13 receptor α-2 (IL13Rα2) is a cell surface receptor frequently expressed in solid malignancies ... effective dosimetry of 177 Lu-labeled KLG-3 therapy. Targeting with KLG-3 was ...

Mechanistically, Rbm24a interacts with the germ plasm component Buc to dictate the specific recruitment of germ plasm mRNAs into phase-separated condensates. Germ plasm particles lacking Rbm24a and ...

Microscopic imaging analysis on Alexa Fluor 647-labeled ASO and Chol-HDO. C57BL/6 mice were injected intravenously with Alexa Fluor 647-labeled ASO and Chol-HDO. At 4 h after injection, the brain ...

Automated production of 11 C-labeled carboxylic acids and esters via "in-loop" 11 C-carbonylation using GE FX synthesis modules.

This resin has previously reported for the synthesis of cyclo thiodepsipeptides and homodetic ... which was then centrifuged and decanted. The remaining solid was dissolved in CH 3 CN-H 2 O (1:1) and ...