NanoCas, a smaller version of CRISPR tested with a single AAV, delivers on-target results
Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform ...
AZoLifeSciences on MSN5d
CRISPR-Cas9 Off-Target Effects: Challenges and Solutions
The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about ...
The Scientist5d
A Gene Drive with a Disappearing Act Can Aid Pest Control
A CRISPR-based system that erases itself from fly populations may offer a safer approach to tackling insecticide resistance ...
chromatographyonline16d
Understanding the On-off Retention Mechanism of Oligonucleotides
A team from the University of Geneva and Bayer AG present their findings on the on-off retention of oligonucleotides and the ...
Nature8d
Molecular biology articles from across Nature Portfolio
Such screens genetically perturb many genes in parallel and use single-cell RNA sequencing to assess the ... transposon-based delivery of the CRISPR guide RNAs. The selective destruction of ...
Nature7d
Genetics articles from across Nature Portfolio
Such screens genetically perturb many genes in parallel and use single-cell RNA sequencing to assess the ... transposon-based delivery of the CRISPR guide RNAs.
mskcc.org6y
RNA Decay
Our investigations of exosomes in budding yeast revealed that its central channel is essential, and that it functions to guide ... optimized DNA-RNA chimera that stalls the MTR4 helicase during ...
Nanowerk3y
RNA: The Versatile Molecule of Life
RNA is similar to DNA but contains uracil instead of thymine (T) and has a single-stranded structure. Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases ...