To the cell biologist, however, 'endothelial cell dysfunction' may represent an alteration of an extensive gene program and changes in a host of signaling pathways and secreted factors.

Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.

His research focused on investigating the role of Neuropilin-1 in endothelial and vascular resilience, particularly in promoting signalling pathways protecting endothelial cell function and preventing ...

By assessing gene expression changes in endothelial cells, the team found that AHR-deficient mice showed disruption of the apelin signaling pathway, which is involved in vessel function regulation.

LMU researchers identify a crucial signaling pathway—with therapeutic potential ... RNA sequencing and 3D microscopy revealed ...

Glomerular endothelial cells (GEnC)characterised by non-diaphragmed ... protective effect of INFβ in animal models of diabetic nephropathy and downstream signalling pathways within our GEnC lines.