Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.

By assessing gene expression changes in endothelial cells, the team found that AHR-deficient mice showed disruption of the apelin signaling pathway, which is involved in vessel function regulation.

LMU researchers identify a crucial signaling pathway—with therapeutic potential ... RNA sequencing and 3D microscopy revealed ...

Stimulation of endothelial cells with ephrin-B2 in the absence of VEGF-C triggers VEGFR-3 internalization but cannot activate signaling, indicating functional cooperation between both pathways.