Animal welfare groups had long accused the National Institutes of Health of killing thousands of beagles in septic shock experiments.

Time-restricted feeding (TRF) is a promising dietary regime, but its role in septic liver injury remains unknown. Using 16S rRNA gene sequencing, Q200 targeted metabolomics, transcriptomics, germ-free ...

Blocking CD47-Aβ signaling significantly reduces organ injury and improves the survival rate of septic mice by restoring phagocytic cell functions and alleviating B-cell suppression and adaptive ...

This study aimed to investigate the effects of Shenfu Decoction on the chemotactic function of neutrophils in septic mice and the underlying mechanisms. Thirty 10-week-old specific-pathogen-free ...

Cmtm3 knockout improves the survival rate of septic mice, mitigate inflammatory responses, and ameliorate organ damage. Mechanistically, the deletion of Cmtm3 reduced the expression of Toll-like ...

According to the Global Burden of Disease study, about 50 million people annually worldwide develop severe sepsis or septic shock, and 11 million of them die. Growing evidence suggests that changes to ...

M2-Exos reduced NET formation and PMN migration, relieved lung damage, and increased septic mouse survival time. M2-Exos significantly reduced NET formation and PMN migration capability in vitro ...

Consequently, the fecal peritonitis (FP)-induced septic mice with the higher levels of tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), IL-1β, malondialdehyde (MDA), myeloperoxidase (MPO), ...

When plasma samples of septic mice exposed to the FAK-PyK2 inhibitor were evaluated, the concentrations of the same biomarkers were found at levels similar to those detected in the sham group (49.04 ± ...

In a new study, researchers at UC Santa Cruz have identified a long noncoding RNA (lncRNA) molecule that regulates the expression of pro-inflammatory genes in immune system cells called macrophages ...