Human vesicular polyamine transporter underpins learning and memory formation by loading polyamines into secretory vesicles. Here, the authors decipher the transporter structure and suggest an ...

Vesicles are small blisters that can appear on your skin. They can be a symptom of a medical issue or a sign of tissue injury. Some conditions, like contact dermatitis or cold sores, may not ...

histolytica serine proteinase; EhSTIRP = Serine threonine isoleucine-rich protein; KERP1 = Lysine and glutamic acid-rich protein-1; MUC2 = Secretory mucin; LPPG = Lipophosphopeptidoglycan ...

Cellular communication is a critical process that relies on exocytosis, during which cells release stored chemical messengers contained within intracellular nanoscale vesicles (50–500 nm in diameter).

Recent efforts directed on understanding the epigenetic regulation of allergic response, mechanisms of immunologic tolerance breakdown, role of extracellular vesicles in the development of allergy ...

Attribution (BY): Credit must be given to the creator. Single extracellular vesicle (EV) research holds the potential to revolutionize our understanding of cellular communication and enable ...

Given the contribution of EC-derived EVs to atherosclerosis, this model represents the first in vivo murine approach to tracking intercellular EC-EV communication within the plaque. It provides an ...

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

We provide evidence that Upd2 transport requires Rab5- and Rab7-mediated endocytic sorting and Lbm-dependent vesicle trafficking. Our study thus uncovers an inter-organ communication in the control of ...

Here, we describe the isolation and structure determination of proteins in membrane vesicles derived directly from cells. Structures of the ion channel Slo1 from total cell membranes and from cell ...

Circulating exosomes in Xinji fine-wool and small-tailed Han sheep altered the hair growth in mice. Circulating exosomes are microscopic vesicles secreted by cells that circulate in the body via the ...