A combination of three drugs — one of them the experimental therapy CuATSM — may be effective for treating amyotrophic lateral sclerosis (ALS) caused by mutations in the SOD1 gene, according to a new ...

Here, we found that the progression of NMJ denervation prior to the onset of muscle weakness in SOD1-93A mouse model of ALS correlated with increased serum MuSK immunoreactivity and elevated MuSK ...

There can also be selective vulnerability by physiological subtypes of motoneurons. Pun et al30 showed in two mouse models of motoneuron disease (G93A SOD1 and G85R SOD1) that axons of fast fatigable ...

[39] Soo, Atkin, Farg, Walker, Horne, and Nagley (2012) Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic ... striatal co-cultures from Huntington's disease ...

The level of SOD1 (Cu/Zn-SOD) and SOD2 (Mn-SOD ... Notably, the absence of adverse effects at 300 mg/kg contrasts with reports of high-dose AMP toxicity in mice (40, 41), suggesting pigeons may ...

The new Mickey Mouse Clubhouse show at Disney California Adventure seeks to give kids a chance to dance, sing and burn off a little nervous energy while their parents cool their heels in air ...

Switch 2's mouse controls will be usable in the console's Home menu. As shared in the Nintendo Today app, mouse controls won't just be for in-game but for navigating menus - there's a video of it ...

Xiaomi has officially introduced the Wireless Mouse Lite 3 in China, adding to its lineup of affordable peripheral devices. The new model is currently available for pre-order through JD.com and ...

The new Razer Pro Click V2 Vertical Edition brings ergonomics to the RGB party. The new Razer Pro Click V2 Vertical Edition brings ergonomics to the RGB party. Antonio G. Di Benedetto is a ...