These findings were also supported by a more recent characterization of the model, where Rotarod performance was impaired relative to control wild-type mice as early as 6 weeks of age (Radisavljevic ...

as well as healthy control mice. This included the rotarod test, which measures the time until the animal falls from a rotating rod that accelerates from 5 to 50 rpm over 5 min, and the pole test, ...

These mice also demonstrated improved neurological and motor function, as measured by standardized tests such as the Bederson test and the rotarod performance test. These improvements provide furt ...

Importantly, the nocifensive responses and behavior of these mice in other pain assays in the absence of stress (e.g., hotplate) and a few standard assays (open field, rotarod, elevated plus maze) ...

The authors use acute restraint stress as a stress paradigm and found that following one hour of restraint stress mice display mechanical hypersensitivity. They show that restraint stress causes the ...

Mice were tested with multiple behavioral experiments ... Two behavioral assays were used: an open field test to assess spontaneous motor activity, and a rotarod test to evaluate motor coordination.

Fall latency (s) was recorded. For both weeks of testing, mice received three subsequent trials on two subsequent days. The outcome measure in the rotarod test used was the mean fall latency of each ...

Methods EM48 antibody was daily administered for 5 weeks, at dose of 0.1 mg/kg of body weight, in R6/2 mice and wild-type (WT) littermates, starting from the V week of age. Motor deficit was assessed ...