Ribosome biogenesis — from the synthesis of the core ribosomal constituents, RPs and rRNA, to their assembly and transport — is the most energy-consuming anabolic process in human cells (Box 2).

Approximately 30% of the nucleolar proteome consists of proteins involved in ribosome biogenesis, marking the nucleolus as the central location for ribosome assembly (Boisvert et al., 2007).

A somatic ribosomal protein mutation can therefore promote the transformation of cancer but will not be sufficient on its own to cause it. They and mutations in ribosome biogenesis factors can ...

The yellow cells, indicated by arrows, are the first evidence of increased ribosome biogenesis in cells during epithelial-to-mesenchymal transition (EMT). [Vincent et al.] Researchers from Uppsala ...

"The relatively compact phenotype of the 90S pre-ribosome gave us the idea that this shell, in combination with other factors, encloses the smaller of the two ribosomal subunits during biogenesis ...

6 Mendell said, “Almost all of the factors that we know that are involved in building ribosomes are things that positively regulate ribosomal biogenesis.” This is undesirable because therapeutics that ...

Owing to the enormous complexity of the ribosome, the assembly process employs upwards of 200 non-ribosomal biogenesis factors that function transiently. The first structure that results from pre ...

The process of ribosome biogenesis involves the transcription of rRNA precursors, their processing and modification, and the association with ribosomal proteins to form the mature ribosomal subunits.

Since ribosomal proteins play a crucial role in ribosome biogenesis, these findings prompted scientists to investigate the role of MAR and RPL27A in the regulation of mature rRNA abundance and ...

Their study therefore argues that ribosome biogenesis may be more than just a pro-proliferative process. "Until recently, ribosomes have been considered to play only passive roles during the ...

CX-3543, Cylene's most advanced product for the treatment of multiple cancers, acts as a Ribosomal RNA Biogenesis Inhibitor (RBI) by targeting a Protein:DNA interaction that is amplified in cancer ...

MYC activity signature 2, which is enriched with genes involved in RNA processing and ribosomal biogenesis, was higher in this subtype. The basal immune subtype had higher levels of tumor ...